DPYD Exome, mRNA Expression and Uracil Levels in Early Severe Toxicity to Fluoropyrimidines: An Extreme Phenotype Approach

Dihydropyrimidine dehydrogenase deficiency is a major cause of severe fluoropyrimidine-induced toxicity and could lead to interruption of chemotherapy or life-threatening adverse reactions. This study aimed to characterize the DPYD exon sequence, mRNA expression and in vivo DPD activity by plasma ur...

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Detalles Bibliográficos
Autores principales: Villalvazo, Priscila, Marzal-Alfaro, Belén, García-Alfonso, Pilar, Revuelta-Herrero, José Luis, Thomas, Fabienne, López-Tarruella, Sara, García-González, Xandra, Calvo, Aitana, Yakoubi, Malika, Salvador-Martín, Sara, López-López, Flora, Aguilar, Iker, Sanjurjo-Sáez, María, Martín, Miguel, López-Fernández, Luis Andrés
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8401253/
https://www.ncbi.nlm.nih.gov/pubmed/34442436
http://dx.doi.org/10.3390/jpm11080792

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8401253/
https://www.ncbi.nlm.nih.gov/pubmed/34442436
http://dx.doi.org/10.3390/jpm11080792

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