Cargando…

Landscape of T‐cell repertoires with public COVID‐19‐associated T‐cell receptors in pre‐pandemic risk cohorts

OBJECTIVES: T cells have an essential role in the antiviral defence. Public T‐cell receptor (TCR) clonotypes are expanded in a substantial proportion of COVID‐19 patients. We set out to exploit their potential use as read‐out for COVID‐19 T‐cell immune responses. METHODS: We searched for COVID‐19‐as...

Descripción completa

Detalles Bibliográficos
Autores principales:	Simnica, Donjete, Schultheiß, Christoph, Mohme, Malte, Paschold, Lisa, Willscher, Edith, Fitzek, Antonia, Püschel, Klaus, Matschke, Jakob, Ciesek, Sandra, Sedding, Daniel G, Zhao, Yu, Gagliani, Nicola, Maringer, Yacine, Walz, Juliane S, Heide, Janna, Schulze‐zur‐Wiesch, Julian, Binder, Mascha
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8401425/ https://www.ncbi.nlm.nih.gov/pubmed/34484739 http://dx.doi.org/10.1002/cti2.1340

Ejemplares similares

Next-Generation Sequencing of T and B Cell Receptor Repertoires from COVID-19 Patients Showed Signatures Associated with Severity of Disease
por: Schultheiß, Christoph, et al.
Publicado: (2020)

Azacitidine-induced reconstitution of the bone marrow T cell repertoire is associated with superior survival in AML patients
por: Grimm, Juliane, et al.
Publicado: (2022)

Rapid Hypermutation B Cell Trajectory Recruits Previously Primed B Cells Upon Third SARS-Cov-2 mRNA Vaccination
por: Paschold, Lisa, et al.
Publicado: (2022)

Maturation trajectories and transcriptional landscape of plasmablasts and autoreactive B cells in COVID-19
por: Schultheiß, Christoph, et al.
Publicado: (2021)

Subclonal heterogeneity sheds light on the transformation trajectory in IGLV3-21(R110) chronic lymphocytic leukemia
por: Paschold, Lisa, et al.
Publicado: (2022)

PD-L1 Amino Acid Position 88 Represents a Hotspot for PD-L1 Stability With Relevance for PD-L1 Inhibition
por: Claaß, Luise Victoria, et al.
Publicado: (2022)

Identification of a unique TCR repertoire, consistent with a superantigen selection process in Children with Multi-system Inflammatory Syndrome
por: Porritt, Rebecca A, et al.
Publicado: (2020)

Immune signatures in variant syndromes of primary biliary cholangitis and autoimmune hepatitis
por: Schultheiß, Christoph, et al.
Publicado: (2023)

Targeting the Mutational Landscape of Bystander Cells: Drug-Promoted Blood Cancer From High-Prevalence Pre-neoplasias in Patients on BRAF Inhibitors
por: Simnica, Donjete, et al.
Publicado: (2020)

SLAMF receptors negatively regulate B cell receptor signaling in chronic lymphocytic leukemia via recruitment of prohibitin-2
por: von Wenserski, Lisa, et al.
Publicado: (2020)

Superantigenic character of an insert unique to SARS-CoV-2 spike supported by skewed TCR repertoire in patients with hyperinflammation
por: Cheng, Mary Hongying, et al.
Publicado: (2020)

Liquid biomarkers of macrophage dysregulation and circulating spike protein illustrate the biological heterogeneity in patients with post‐acute sequelae of COVID‐19
por: Schultheiß, Christoph, et al.
Publicado: (2022)

Evolutionary clonal trajectories in nodular lymphocyte-predominant Hodgkin lymphoma with high risk of transformation
por: Paschold, Lisa, et al.
Publicado: (2021)

The IL-1β, IL-6, and TNF cytokine triad is associated with post-acute sequelae of COVID-19
por: Schultheiß, Christoph, et al.
Publicado: (2022)

Characterization of the T cell receptor repertoire and melanoma tumor microenvironment upon combined treatment with ipilimumab and hTERT vaccination
por: Ellingsen, Espen Basmo, et al.
Publicado: (2022)

High-Throughput Immunogenetics Reveals a Lack of Physiological T Cell Clusters in Patients With Autoimmune Cytopenias
por: Simnica, Donjete, et al.
Publicado: (2019)

Circulating Tumor DNA in Gastric and Gastroesophageal Junction Cancer
por: Paschold, Lisa, et al.
Publicado: (2022)

PD-L1 targeting and subclonal immune escape mediated by PD-L1 mutations in metastatic colorectal cancer
por: Stein, Alexander, et al.
Publicado: (2021)

Translational analysis and final efficacy of the AVETUX trial – Avelumab, cetuximab and FOLFOX in metastatic colorectal cancer
por: Tintelnot, Joseph, et al.
Publicado: (2022)

Comprehensive Review of Human Plasmodium falciparum-Specific CD8+ T Cell Epitopes
por: Heide, Janna, et al.
Publicado: (2019)

T cell repertoire breadth is associated with the number of acute respiratory infections in the LoewenKIDS birth cohort
por: Paschold, Lisa, et al.
Publicado: (2023)

Immunopeptidome Diversity in Chronic Lymphocytic Leukemia Identifies Patients with Favorable Disease Outcome
por: Marconato, Maddalena, et al.
Publicado: (2022)

Deep sequencing of bone marrow microenvironments of patients with del(5q) myelodysplastic syndrome reveals imprints of antigenic selection as well as generation of novel T-cell clusters as a response pattern to lenalidomide
por: Mährle, Thorben, et al.
Publicado: (2019)

Overcoming unintended immunogenicity in immunocompetent mouse models of metastasis: the case of GFP
por: Schultheiß, Christoph, et al.
Publicado: (2022)

First-line treatment of unresectable or metastatic HER2 positive esophagogastric adenocarcinoma: liquid biomarker analysis of the phase 2 INTEGA trial
por: Paschold, Lisa, et al.
Publicado: (2023)

Elevated SARS-CoV-2-Specific Antibody Levels in Patients with Post-COVID Syndrome
por: Hackenbruch, Christopher, et al.
Publicado: (2023)

Detection of EXP1-Specific CD4+ T Cell Responses Directed Against a Broad Range of Epitopes Including Two Promiscuous MHC Class II Binders During Acute Plasmodium falciparum Malaria
por: Heide, Janna, et al.
Publicado: (2020)

Prevalence of COVID-19-associated symptoms during acute infection in relation to SARS-CoV-2-directed humoral and cellular immune responses in a mild-diseased convalescent cohort
por: Tegeler, Christian M., et al.
Publicado: (2022)

Durable spike-specific T cell responses after different COVID-19 vaccination regimens are not further enhanced by booster vaccination
por: Maringer, Yacine, et al.
Publicado: (2022)

Immunoprecipitation methods impact the peptide repertoire in immunopeptidomics
por: Wacker, Marcel, et al.
Publicado: (2023)

Curse and blessing: upregulation of oncogenes upon treatment with hypomethylating agents in myelodysplastic syndrome
por: Grimm, Juliane, et al.
Publicado: (2022)

B cells in autoimmune hepatitis: bystanders or central players?
por: Schultheiß, Christoph, et al.
Publicado: (2022)

Circulating Tumor DNA in Head and Neck Squamous Cell Carcinoma
por: Brandt, Anna, et al.
Publicado: (2023)

Impact of bone marrow involvement on outcome in relapsed and refractory transplant eligible diffuse large B-cell lymphoma and transformed indolent lymphoma
por: Terziev, Denis, et al.
Publicado: (2020)

Post-mortem histopathology of pituitary and adrenals of COVID-19 patients
por: Fitzek, Antonia, et al.
Publicado: (2022)

Detection of SARS-CoV-2 genomic and subgenomic RNA in retina and optic nerve of patients with COVID-19
por: Casagrande, Maria, et al.
Publicado: (2022)

Vagus nerve inflammation contributes to dysautonomia in COVID-19
por: Woo, Marcel S., et al.
Publicado: (2023)

Detection of SARS-CoV-2 Derived Small RNAs and Changes in Circulating Small RNAs Associated with COVID-19
por: Grehl, Claudius, et al.
Publicado: (2021)

Alterations in function and distribution of regulatory T Cells (Tregs) may blunt vaccine induced immune responses in HIV infection
por: van Lunzen, J, et al.
Publicado: (2012)

Human hepatitis D virus-specific T cell epitopes
por: Kohsar, Matin, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_28b5c61cn5dhnct5ssigilvefp