Thermodynamic Stability Is a Strong Predictor for the Delivery of DARPins to the Cytosol via Anthrax Toxin

Anthrax toxin has evolved to translocate its toxic cargo proteins to the cytosol of cells carrying its cognate receptor. Cargo molecules need to unfold to penetrate the narrow pore formed by its membrane-spanning subunit, protective antigen (PA). Various alternative cargo molecules have previously b...

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Detalles Bibliográficos
Autores principales: Becker, Lukas, Singh Badwal, Jasleen, Brandl, Fabian, Verdurmen, Wouter P. R., Plückthun, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8401532/
https://www.ncbi.nlm.nih.gov/pubmed/34452246
http://dx.doi.org/10.3390/pharmaceutics13081285

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8401532/
https://www.ncbi.nlm.nih.gov/pubmed/34452246
http://dx.doi.org/10.3390/pharmaceutics13081285

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