Structural Characterization of a Macrocyclic Peptide Modulator of the PD-1/PD-L1 Immune Checkpoint Axis

The clinical success of PD-1/PD-L1 immune checkpoint targeting antibodies in cancer is followed by efforts to develop small molecule inhibitors with better penetration into solid tumors and more favorable pharmacokinetics. Here we report the crystal structure of a macrocyclic peptide inhibitor (pept...

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Detalles Bibliográficos
Autores principales: Zyla, Edyta, Musielak, Bogdan, Holak, Tad A., Dubin, Grzegorz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8401550/
https://www.ncbi.nlm.nih.gov/pubmed/34443436
http://dx.doi.org/10.3390/molecules26164848

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8401550/
https://www.ncbi.nlm.nih.gov/pubmed/34443436
http://dx.doi.org/10.3390/molecules26164848

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