Processing Impact on In Vitro and In Vivo Performance of Solid Dispersions—A Comparison between Hot-Melt Extrusion and Spray Drying

Presently, a large number of drug molecules in development are BCS class II or IV compounds with poor aqueous solubility. Various novel solubilization techniques have been used to enhance drug solubility. Among them, amorphous solid dispersions (ASD), which convert a crystalline drug into an amorpho...

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Detalles Bibliográficos
Autores principales: Li, Yongjun, Mann, Amanda K. P., Zhang, Dan, Yang, Zhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8401923/
https://www.ncbi.nlm.nih.gov/pubmed/34452269
http://dx.doi.org/10.3390/pharmaceutics13081307

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8401923/
https://www.ncbi.nlm.nih.gov/pubmed/34452269
http://dx.doi.org/10.3390/pharmaceutics13081307

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