ROCK2-Specific Inhibitor KD025 Suppresses Adipocyte Differentiation by Inhibiting Casein Kinase 2

KD025, a ROCK2 isoform-specific inhibitor, has an anti-adipogenic activity which is not mediated by ROCK2 inhibition. To identify the target, we searched binding targets of KD025 by using the KINOMEscan(TM) screening platform, and we identified casein kinase 2 (CK2) as a novel target. KD025 showed c...

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Detalles Bibliográficos
Autores principales: Tran, Nhu Nguyen Quynh, Chun, Kwang-Hoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8401933/
https://www.ncbi.nlm.nih.gov/pubmed/34443331
http://dx.doi.org/10.3390/molecules26164747

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8401933/
https://www.ncbi.nlm.nih.gov/pubmed/34443331
http://dx.doi.org/10.3390/molecules26164747

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