Metformin Decreases 2-HG Production through the MYC-PHGDH Pathway in Suppressing Breast Cancer Cell Proliferation

The biguanide drug metformin has been widely used for the treatment of type 2 diabetes, and there is evidence supporting the anticancer effect of metformin despite some controversy. Here, we report the growth inhibitory activity of metformin in the breast cancer (MCF-7) cells, both in vitro and in v...

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Detalles Bibliográficos
Autores principales: Oh, Sehyun, Cho, Youngup, Chang, Minsun, Park, Sunghyouk, Kwon, Hyuknam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402004/
https://www.ncbi.nlm.nih.gov/pubmed/34436421
http://dx.doi.org/10.3390/metabo11080480

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402004/
https://www.ncbi.nlm.nih.gov/pubmed/34436421
http://dx.doi.org/10.3390/metabo11080480

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