The Allosteric Activation of α7 nAChR by α-Conotoxin MrIC Is Modified by Mutations at the Vestibular Site

α-conotoxins are 13–19 amino acid toxin peptides that bind various nicotinic acetylcholine receptor (nAChR) subtypes. α-conotoxin Mr1.7c (MrIC) is a 17 amino acid peptide that targets α7 nAChR. Although MrIC has no activating effect on α7 nAChR when applied by itself, it evokes a large response when...

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Detalles Bibliográficos
Autores principales: Gulsevin, Alican, Papke, Roger L., Stokes, Clare, Tran, Hue N. T., Jin, Aihua H., Vetter, Irina, Meiler, Jens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402416/
https://www.ncbi.nlm.nih.gov/pubmed/34437426
http://dx.doi.org/10.3390/toxins13080555

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402416/
https://www.ncbi.nlm.nih.gov/pubmed/34437426
http://dx.doi.org/10.3390/toxins13080555

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