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Primary Human Renal Proximal Tubular Epithelial Cells (pHRPTEpiCs): Shiga Toxin (Stx) Glycosphingolipid Receptors, Stx Susceptibility, and Interaction with Membrane Microdomains

Tubular epithelial cells of the human kidney are considered as targets of Shiga toxins (Stxs) in the Stx-mediated pathogenesis of hemolytic–uremic syndrome (HUS) caused by Stx-releasing enterohemorrhagic Escherichia coli (EHEC). Analysis of Stx-binding glycosphingolipids (GSLs) of primary human rena...

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Detalles Bibliográficos
Autores principales: Detzner, Johanna, Klein, Anna-Lena, Pohlentz, Gottfried, Krojnewski, Elisabeth, Humpf, Hans-Ulrich, Mellmann, Alexander, Karch, Helge, Müthing, Johannes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402424/
https://www.ncbi.nlm.nih.gov/pubmed/34437399
http://dx.doi.org/10.3390/toxins13080529