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In Vivo Models and In Vitro Assays for the Assessment of Pertussis Toxin Activity
One of the main virulence factors produced by Bordetella pertussis is pertussis toxin (PTx) which, in its inactivated form, is the major component of all marketed acellular pertussis vaccines. PTx ADP ribosylates Gα(i) proteins, thereby affecting the inhibition of adenylate cyclases and resulting in...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8402560/ https://www.ncbi.nlm.nih.gov/pubmed/34437436 http://dx.doi.org/10.3390/toxins13080565 |