A Novel CD73 Inhibitor SHR170008 Suppresses Adenosine in Tumor and Enhances Anti-Tumor Activity with PD-1 Blockade in a Mouse Model of Breast Cancer

INTRODUCTION: CD73 and adenosine support growth-promoting neovascularization, metastasis, and survival in cells, and promote anti-PD-1 mAb therapy-induced immune escape. Consequently, developing a CD73 inhibitor as monotherapy and a potential beneficial combination partner with immune-checkpoint inh...

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Detalles Bibliográficos
Autores principales: Liu, Suxing, Li, Di, Liu, Jian, Wang, Huiyun, Horecny, Ivana, Shen, Ru, Zhang, Rumin, Wu, Heping, Hu, Qiyue, Zhao, Peng, Zhang, Fengqi, Yan, Yinfa, Feng, Jun, Zhuang, Linghang, Li, Jing, Zhang, Lianshan, Tao, Weikang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8403083/
https://www.ncbi.nlm.nih.gov/pubmed/34466002
http://dx.doi.org/10.2147/OTT.S326178

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8403083/
https://www.ncbi.nlm.nih.gov/pubmed/34466002
http://dx.doi.org/10.2147/OTT.S326178

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