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Derivation and characterization of an HIV-1 mutant that rescues IP(6) binding deficiency

BACKGROUND: A critical step in the HIV-1 replication cycle is the assembly of Gag proteins to form virions at the plasma membrane. Virion assembly and maturation are facilitated by the cellular polyanion inositol hexaphosphate (IP(6)), which is proposed to stabilize both the immature Gag lattice and...

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Detalles Bibliográficos
Autores principales: Poston, Daniel, Zang, Trinity, Bieniasz, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8403458/
https://www.ncbi.nlm.nih.gov/pubmed/34454514
http://dx.doi.org/10.1186/s12977-021-00571-3