Low endotoxin E. coli strain-derived plasmids reduce rAAV vector-mediated immune responses both in vitro and in vivo

The major challenge of recombinant adeno-associated virus (rAAV) vectors is host immunological barriers. Compared to the neutralizing antibody and the cytotoxic T lymphocyte response, the host immune responses induced by unsatisfactory rAAV manufacturing were largely ignored previously. rAAV vector...

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Detalles Bibliográficos
Autores principales: Zheng, Qingyun, Wang, Tianyi, Zhu, Xiangying, Tian, Xiao, Zhong, Chen, Chang, Guolin, Ran, Gai, Xie, Yilin, Zhao, Bing, Zhu, Liqing, Ling, Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8403685/
https://www.ncbi.nlm.nih.gov/pubmed/34485612
http://dx.doi.org/10.1016/j.omtm.2021.06.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8403685/
https://www.ncbi.nlm.nih.gov/pubmed/34485612
http://dx.doi.org/10.1016/j.omtm.2021.06.009

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