Nanoparticles of a New Small-Molecule P-Selectin Inhibitor Attenuate Thrombosis, Inflammation, and Tumor Growth in Two Animal Models

PURPOSE: To assess whether the newly designed small-molecule oral P-selectin inhibitor 3S-1,2,3,4-tetrahydro-β-carboline-3-methyl aspartyl ester (THCMA) as a nanomedicine enhances antithrombosis, anti-inflammation, and antitumor activity more than the clinical trial drug PSI-697. METHODS: THCMA was...

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Detalles Bibliográficos
Autores principales: Feng, Qiqi, Wang, Mengyang, Muhtar, Eldar, Wang, Yaonan, Zhu, Haimei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8403725/
https://www.ncbi.nlm.nih.gov/pubmed/34471352
http://dx.doi.org/10.2147/IJN.S316863

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8403725/
https://www.ncbi.nlm.nih.gov/pubmed/34471352
http://dx.doi.org/10.2147/IJN.S316863

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