TET2 as a tumor suppressor and therapeutic target in T-cell acute lymphoblastic leukemia

Pediatric T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy resulting from overproduction of immature T-cells in the thymus and is typified by widespread alterations in DNA methylation. As survival rates for relapsed T-ALL remain dismal (10 to 25%), development of targeted ther...

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Detalles Bibliográficos
Autores principales: Bensberg, Maike, Rundquist, Olof, Selimović, Aida, Lagerwall, Cathrine, Benson, Mikael, Gustafsson, Mika, Vogt, Hartmut, Lentini, Antonio, Nestor, Colm E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8403940/
https://www.ncbi.nlm.nih.gov/pubmed/34413196
http://dx.doi.org/10.1073/pnas.2110758118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8403940/
https://www.ncbi.nlm.nih.gov/pubmed/34413196
http://dx.doi.org/10.1073/pnas.2110758118

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