Inhibition of elastase enhances the adjuvanticity of alum and promotes anti–SARS-CoV-2 systemic and mucosal immunity

Alum, used as an adjuvant in injected vaccines, promotes T helper 2 (Th2) and serum antibody (Ab) responses. However, it fails to induce secretory immunoglobulin (Ig) A (SIgA) in mucosal tissues and is poor in inducing Th1 and cell-mediated immunity. Alum stimulates interleukin 1 (IL-1) and the recr...

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Detalles Bibliográficos
Autores principales: Kim, Eunsoo, Attia, Zayed, Woodfint, Rachel M., Zeng, Cong, Kim, Sun Hee, Steiner, Haley E., Shukla, Rajni Kant, Liyanage, Namal P. M., Ghimire, Shristi, Li, Jianrong, Renukaradhya, Gourapura J., Satoskar, Abhay R., Amer, Amal O., Liu, Shan-Lu, Cormet-Boyaka, Estelle, Boyaka, Prosper N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8403952/
https://www.ncbi.nlm.nih.gov/pubmed/34353890
http://dx.doi.org/10.1073/pnas.2102435118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8403952/
https://www.ncbi.nlm.nih.gov/pubmed/34353890
http://dx.doi.org/10.1073/pnas.2102435118

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