Conserved cholesterol-related activities of Dispatched 1 drive Sonic hedgehog shedding from the cell membrane

The Sonic hedgehog (Shh) pathway controls embryonic development and tissue homeostasis after birth. Long-standing questions about this pathway include how the dual-lipidated, firmly plasma membrane-associated Shh ligand is released from producing cells to signal to distant target cells and how the r...

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Detalles Bibliográficos
Autores principales: Ehring, Kristina, Manikowski, Dominique, Goretzko, Jonas, Froese, Jurij, Gude, Fabian, Jakobs, Petra, Rescher, Ursula, Kirchhefer, Uwe, Grobe, Kay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8403983/
https://www.ncbi.nlm.nih.gov/pubmed/34308968
http://dx.doi.org/10.1242/jcs.258672

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8403983/
https://www.ncbi.nlm.nih.gov/pubmed/34308968
http://dx.doi.org/10.1242/jcs.258672

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