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Induced fit versus conformational selection: From rate constants to fluxes… and back to rate constants
Induced fit‐ (IF) and conformational selection (CS) binding mechanisms have long been regarded to be mutually exclusive. Yet, they are now increasingly considered to produce the final ligand‐target complex alongside within a thermodynamic cycle. This viewpoint benefited from the introduction of bind...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8404059/ https://www.ncbi.nlm.nih.gov/pubmed/34459109 http://dx.doi.org/10.1002/prp2.847 |