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Brucella melitensis UGPase inhibits the activation of NF-κB by modulating the ubiquitination of NEMO

BACKGROUND: UTP-glucose-1-phosphoryl transferase (UGPase) catalyzes the synthesis of UDP-glucose, which is essential for generating the glycogen needed for the synthesis of bacterial lipopolysaccharide (LPS) and capsular polysaccharide, which play important roles in bacterial virulence. However, the...

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Detalles Bibliográficos
Autores principales: Zhou, Yucheng, Bu, Zhaoyang, Qian, Jing, Cheng, Yuening, Qiao, Lianjiang, Yang, Sen, Cheng, Shipeng, Wang, Xinglong, Ren, Linzhu, Yang, Yanling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8404259/
https://www.ncbi.nlm.nih.gov/pubmed/34461896
http://dx.doi.org/10.1186/s12917-021-02993-9