GB1275, a first-in-class CD11b modulator: rationale for immunotherapeutic combinations in solid tumors

Resistance to immune checkpoint inhibitors (ICI) and other anticancer therapies is often associated with the accumulation of myeloid-derived suppressor cells (MDSCs) and tumor-associated macrophages (TAMs) in the tumor microenvironment (TME). Therefore, targeting MDSC recruitment or function is of s...

Descripción completa

Detalles Bibliográficos
Autores principales: DeNardo, David G, Galkin, Anna, Dupont, Jakob, Zhou, Lei, Bendell, Johanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Clinical Trials Monitor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8404448/
https://www.ncbi.nlm.nih.gov/pubmed/34452928
http://dx.doi.org/10.1136/jitc-2021-003005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8404448/
https://www.ncbi.nlm.nih.gov/pubmed/34452928
http://dx.doi.org/10.1136/jitc-2021-003005

Ejemplares similares