Depolarization induces nociceptor sensitization by Ca(V)1.2-mediated PKA-II activation

Depolarization drives neuronal plasticity. However, whether depolarization drives sensitization of peripheral nociceptive neurons remains elusive. By high-content screening (HCS) microscopy, we revealed that depolarization of cultured sensory neurons rapidly activates protein kinase A type II (PKA-I...

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Detalles Bibliográficos
Autores principales: Isensee, Jörg, van Cann, Marianne, Despang, Patrick, Araldi, Dioneia, Moeller, Katharina, Petersen, Jonas, Schmidtko, Achim, Matthes, Jan, Levine, Jon D., Hucho, Tim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8404467/
https://www.ncbi.nlm.nih.gov/pubmed/34431981
http://dx.doi.org/10.1083/jcb.202002083

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8404467/
https://www.ncbi.nlm.nih.gov/pubmed/34431981
http://dx.doi.org/10.1083/jcb.202002083

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