Structure-based design of antisense oligonucleotides that inhibit SARS-CoV-2 replication

Antisense oligonucleotides (ASOs) are an emerging class of drugs that target RNAs. Current ASO designs strictly follow the rule of Watson-Crick base pairing along target sequences. However, RNAs often fold into structures that interfere with ASO hybridization. Here we developed a structure-based ASO...

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Detalles Bibliográficos
Autores principales: Li, Yan, Garcia, Gustavo, Arumugaswami, Vaithilingaraja, Guo, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8404888/
https://www.ncbi.nlm.nih.gov/pubmed/34462746
http://dx.doi.org/10.1101/2021.08.23.457434

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8404888/
https://www.ncbi.nlm.nih.gov/pubmed/34462746
http://dx.doi.org/10.1101/2021.08.23.457434

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