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Structure-based design of antisense oligonucleotides that inhibit SARS-CoV-2 replication

Antisense oligonucleotides (ASOs) are an emerging class of drugs that target RNAs. Current ASO designs strictly follow the rule of Watson-Crick base pairing along target sequences. However, RNAs often fold into structures that interfere with ASO hybridization. Here we developed a structure-based ASO...

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Detalles Bibliográficos
Autores principales:	Li, Yan, Garcia, Gustavo, Arumugaswami, Vaithilingaraja, Guo, Feng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8404888/ https://www.ncbi.nlm.nih.gov/pubmed/34462746 http://dx.doi.org/10.1101/2021.08.23.457434

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