Delta spike P681R mutation enhances SARS-CoV-2 fitness over Alpha variant

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SARS-CoV-2 Delta variant has rapidly replaced the Alpha variant around the world. The mechanism that drives this global replacement has not been defined. Here we report that Delta spike mutation P681R plays a key role in the Alpha-to-Delta variant replacement. In a replication competition assay, Del...

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Detalles Bibliográficos
Autores principales: Liu, Yang, Liu, Jianying, Johnson, Bryan A., Xia, Hongjie, Ku, Zhiqiang, Schindewolf, Craig, Widen, Steven G., An, Zhiqiang, Weaver, Scott C., Menachery, Vineet D., Xie, Xuping, Shi, Pei-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8404900/
https://www.ncbi.nlm.nih.gov/pubmed/34462752
http://dx.doi.org/10.1101/2021.08.12.456173

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8404900/
https://www.ncbi.nlm.nih.gov/pubmed/34462752
http://dx.doi.org/10.1101/2021.08.12.456173

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