2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD)-Inducible Poly-ADP-Ribose Polymerase (TIPARP/PARP7) Catalytic Mutant Mice (Tiparp(H532A)) Exhibit Increased Sensitivity to TCDD-Induced Hepatotoxicity and Lethality

2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible poly-adenosine diphosphate (ADP)-ribose polymerase (TIPARP/PARP7), an aryl hydrocarbon receptor (AHR) target gene and mono-ADP-ribosyltransferase, acts as part of a negative feedback loop to repress AHR signaling. This process is prevented by a si...

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Detalles Bibliográficos
Autores principales: Hutin, David, Long, Alexandra S, Sugamori, Kim, Shao, Peng, Singh, Sachin Kumar, Rasmussen, Marit, Olafsen, Ninni Elise, Pettersen, Solveig, Grimaldi, Giulia, Grant, Denis M, Matthews, Jason
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Molecular, Biochemical, and Systems Toxicology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8404992/
https://www.ncbi.nlm.nih.gov/pubmed/34129049
http://dx.doi.org/10.1093/toxsci/kfab075

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8404992/
https://www.ncbi.nlm.nih.gov/pubmed/34129049
http://dx.doi.org/10.1093/toxsci/kfab075

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