Apoptin gene delivery by a PAMAM dendrimer modified with a nuclear localization signal peptide as a gene carrier for brain cancer therapy

In this study, we aimed to synthesize PAMAMG3 derivatives (PAMAMG3-KRRR and PAMAMG3-HKRRR), using KRRR peptides as a nuclear localization signal and introduced histidine residues into the KRRR-grafted PAMAMG3 for delivering a therapeutic, carcinoma cell-selective apoptosis gene, apoptin into human p...

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Detalles Bibliográficos
Autores principales: Bae, Yoonhee, Lee, Jell, Kho, Changwon, Choi, Joon Sig, Han, Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Physiological Society and The Korean Society of Pharmacology 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8405440/
https://www.ncbi.nlm.nih.gov/pubmed/34448464
http://dx.doi.org/10.4196/kjpp.2021.25.5.467

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8405440/
https://www.ncbi.nlm.nih.gov/pubmed/34448464
http://dx.doi.org/10.4196/kjpp.2021.25.5.467

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