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Melatonin modulates nitric oxide-regulated WNK-SPAK/OSR1-NKCC1 signaling in dorsal raphe nucleus of rats

The sleep-wake cycle is regulated by the alternating activity of sleep- and wake-promoting neurons. The dorsal raphe nucleus (DRN) secretes 5-hydroxytryptamine (5-HT, serotonin), promoting wakefulness. Melatonin secreted from the pineal gland also promotes wakefulness in rats. Our laboratory recentl...

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Detalles Bibliográficos
Autores principales: Yang, Hye Jin, Kim, Mi Jung, Kim, Sung Soo, Cho, Young-Wuk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Physiological Society and The Korean Society of Pharmacology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8405441/
https://www.ncbi.nlm.nih.gov/pubmed/34448462
http://dx.doi.org/10.4196/kjpp.2021.25.5.449