Targeting Cellular DNA Damage Responses in Cancer: An In Vitro-Calibrated Agent-Based Model Simulating Monolayer and Spheroid Treatment Responses to ATR-Inhibiting Drugs

We combine a systems pharmacology approach with an agent-based modelling approach to simulate LoVo cells subjected to AZD6738, an ATR (ataxia–telangiectasia-mutated and rad3-related kinase) inhibiting anti-cancer drug that can hinder tumour proliferation by targeting cellular DNA damage responses. T...

Descripción completa

Detalles Bibliográficos
Autores principales: Hamis, Sara, Yates, James, Chaplain, Mark A. J., Powathil, Gibin G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8405495/
https://www.ncbi.nlm.nih.gov/pubmed/34459993
http://dx.doi.org/10.1007/s11538-021-00935-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8405495/
https://www.ncbi.nlm.nih.gov/pubmed/34459993
http://dx.doi.org/10.1007/s11538-021-00935-y

Ejemplares similares