Cargando…

The Smac mimetic BV6 cooperates with STING to induce necroptosis in apoptosis-resistant pancreatic carcinoma cells

Pancreatic cancer (PC) still remains a major cause of cancer-related death worldwide and alternative treatments are urgently required. A common problem of PC is the development of resistance against apoptosis that limits therapeutic success. Here we demonstrate that the prototypical Smac mimetic BV6...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hannes, Sabine, Karlowitz, Rebekka, van Wijk, Sjoerd J. L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8405653/ https://www.ncbi.nlm.nih.gov/pubmed/34462421 http://dx.doi.org/10.1038/s41419-021-04014-x

Ejemplares similares

Smac mimetics and TRAIL cooperate to induce MLKL-dependent necroptosis in Burkitt's lymphoma cell lines
por: Koch, Annkathrin, et al.
Publicado: (2021)

SBP-0636457, a Novel Smac Mimetic, Cooperates with Doxorubicin to Induce Necroptosis in Breast Cancer Cells during Apoptosis Blockage
por: Yu, Rui, et al.
Publicado: (2022)

The SMAC mimetic BV6 sensitizes colorectal cancer cells to ionizing radiation by interfering with DNA repair processes and enhancing apoptosis
por: Hehlgans, Stephanie, et al.
Publicado: (2015)

SMAC Mimetic BV6 Induces Cell Death in Monocytes and Maturation of Monocyte-Derived Dendritic Cells
por: Müller-Sienerth, Nicole, et al.
Publicado: (2011)

SMAC Mimetic BV6 Co-Treatment Downregulates the Factors Involved in Resistance and Relapse of Cancer: IAPs and Autophagy
por: Rafat, Sahar, et al.
Publicado: (2022)

Caspase-8 loss radiosensitizes head and neck squamous cell carcinoma to SMAC mimetic–induced necroptosis
por: Uzunparmak, Burak, et al.
Publicado: (2020)

The Smac Mimetic BV6 Improves NK Cell-Mediated Killing of Rhabdomyosarcoma Cells by Simultaneously Targeting Tumor and Effector Cells
por: Fischer, Kyra, et al.
Publicado: (2017)

Reactivation of Smac-mediated apoptosis in chronic lymphocytic leukemia cells: mechanistic studies of Smac mimetic
por: Balakrishnan, Kumudha, et al.
Publicado: (2016)

USP22 controls necroptosis by regulating receptor‐interacting protein kinase 3 ubiquitination
por: Roedig, Jens, et al.
Publicado: (2020)

Smac mimetic and demethylating agents synergistically trigger cell death in acute myeloid leukemia cells and overcome apoptosis resistance by inducing necroptosis
por: Steinhart, L, et al.
Publicado: (2013)

Future Therapeutic Directions for Smac-Mimetics
por: Morrish, Emma, et al.
Publicado: (2020)

SMG1 and NIK regulate apoptosis induced by Smac mimetic compounds
por: Cheung, H H, et al.
Publicado: (2011)

Quaternary Benzophenanthridine Alkaloids Act as Smac Mimetics and Overcome Resistance to Apoptosis
por: Kulíšková, Petra, et al.
Publicado: (2023)

Smac mimetic-derived augmentation of chemotherapeutic response in experimental pancreatic cancer
por: Awasthi, Niranjan, et al.
Publicado: (2011)

SMAC Mimetic BV6 Enables Sensitization of Resistant Tumor Cells but also Affects Cytokine-Induced Killer (CIK) Cells: A Potential Challenge for Combination Therapy
por: Rettinger, Eva, et al.
Publicado: (2014)

SMAC Mimetics Synergistically Cooperate with HDAC Inhibitors Enhancing TNF-α Autocrine Signaling
por: Shibuya, Yusuke, et al.
Publicado: (2023)

The SMAC Mimetic APG-1387 Sensitizes Immune-Mediated Cell Apoptosis in Hepatocellular Carcinoma
por: Chen, Zide, et al.
Publicado: (2018)

SAHA overcomes FLIP-mediated inhibition of SMAC mimetic-induced apoptosis in mesothelioma
por: Crawford, N, et al.
Publicado: (2013)

Smac mimetic suppresses tunicamycin-induced apoptosis via resolution of ER stress
por: Abhari, Behnaz Ahangarian, et al.
Publicado: (2019)

SMAC mimetics induce autophagy-dependent apoptosis of HIV-1-infected macrophages
por: Campbell, Grant R., et al.
Publicado: (2020)

New light on Smac mimetics and breast cancer
por: Cornmark, L, et al.
Publicado: (2016)

Hyperosmotic stress enhances cytotoxicity of SMAC mimetics
por: Bittner, Sebastian, et al.
Publicado: (2017)

SMAC Mimetics as Therapeutic Agents in HIV Infection
por: Molyer, Bengisu, et al.
Publicado: (2021)

Key necroptotic proteins are required for Smac mimetic-mediated sensitization of cholangiocarcinoma cells to TNF-α and chemotherapeutic gemcitabine-induced necroptosis
por: Akara-amornthum, Perawatt, et al.
Publicado: (2020)

Structural Insight into Inhibitor of Apoptosis Proteins Recognition by a Potent Divalent Smac-Mimetic
por: Cossu, Federica, et al.
Publicado: (2012)

Characterization of Potent SMAC Mimetics that Sensitize Cancer Cells to TNF Family-Induced Apoptosis
por: Welsh, Kate, et al.
Publicado: (2016)

Correction: Smac mimetic suppresses tunicamycin-induced apoptosis via resolution of ER stress
por: Abhari, Behnaz Ahangarian, et al.
Publicado: (2020)

Redox regulation of Smac mimetic-induced cell death
por: Fulda, Simone
Publicado: (2015)

Smac-mimetics reduce numbers and viability of human osteoclasts
por: Moen, Ingrid Nyhus, et al.
Publicado: (2021)

Inhibitor of apoptosis protein expression in glioblastomas and their in vitro and in vivo targeting by SMAC mimetic GDC-0152
por: Tchoghandjian, A, et al.
Publicado: (2016)

Role of RIPK1 in SMAC mimetics-induced apoptosis in primary human HIV-infected macrophages
por: Caballero, Ramon Edwin, et al.
Publicado: (2021)

The role of SMAC mimetics in regulation of tumor cell death and immunity
por: Emeagi, Perpetua U., et al.
Publicado: (2012)

Regulation of cancer stem-like cell differentiation by Smac mimetics
por: Fulda, Simone
Publicado: (2014)

Targeting triple-negative breast cancers with the Smac-mimetic birinapant
por: Lalaoui, Najoua, et al.
Publicado: (2020)

Potency and Selectivity of SMAC/DIABLO Mimetics in Solid Tumor Therapy
por: Zhao, Xiao-Yun, et al.
Publicado: (2020)

USP22 controls type III interferon signaling and SARS-CoV-2 infection through activation of STING
por: Karlowitz, Rebekka, et al.
Publicado: (2022)

Identification of IRF1 as critical dual regulator of Smac mimetic-induced apoptosis and inflammatory cytokine response
por: Eckhardt, I, et al.
Publicado: (2014)

Induction of Breast Cancer Cell Apoptosis by TRAIL and Smac Mimetics: Involvement of RIP1 and cFLIP
por: Holmgren, Christian, et al.
Publicado: (2022)

The Targeted SMAC Mimetic SW IV-134 is a strong enhancer of standard chemotherapy in pancreatic cancer
por: Hashim, Yassar M., et al.
Publicado: (2017)

Smac mimetics and innate immune stimuli synergize to promote tumor death
por: Beug, Shawn T., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_3eahq16i5spr70jfhckivad5km