T-bet represses collagen-induced arthritis by suppressing Th17 lineage commitment through inhibition of RORγt expression and function

T-bet is a key transcription factor for the T helper 1 lineage and its expression level is negatively correlated to inflammation in patients with rheumatoid arthritis (RA). Our previous study using T-bet transgenic mice revealed over-expression of T-bet completely suppressed collagen-induced arthrit...

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Detalles Bibliográficos
Autores principales: Shimizu, Masaru, Kondo, Yuya, Tanimura, Reona, Furuyama, Kotona, Yokosawa, Masahiro, Asashima, Hiromitsu, Tsuboi, Hiroto, Matsumoto, Isao, Sumida, Takayuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8405656/
https://www.ncbi.nlm.nih.gov/pubmed/34462459
http://dx.doi.org/10.1038/s41598-021-96699-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8405656/
https://www.ncbi.nlm.nih.gov/pubmed/34462459
http://dx.doi.org/10.1038/s41598-021-96699-5

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