N-Acetylcysteine prevents amyloid-β secretion in neurons derived from human pluripotent stem cells with trisomy 21

Down syndrome (DS) is caused by the trisomy of chromosome 21. Among the many disabilities found in individuals with DS is an increased risk of early-onset Alzheimer's disease (AD). Although higher oxidative stress and an upregulation of amyloid β (Aβ) peptides from an extra copy of the APP gene...

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Detalles Bibliográficos
Autores principales: Toshikawa, Hiromitsu, Ikenaka, Akihiro, Li, Li, Nishinaka-Arai, Yoko, Niwa, Akira, Ashida, Akira, Kazuki, Yasuhiro, Nakahata, Tatsutoshi, Tamai, Hiroshi, Russell, David W., Saito, Megumu K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8405674/
https://www.ncbi.nlm.nih.gov/pubmed/34462463
http://dx.doi.org/10.1038/s41598-021-96697-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8405674/
https://www.ncbi.nlm.nih.gov/pubmed/34462463
http://dx.doi.org/10.1038/s41598-021-96697-7

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