Therapeutic targeting of both dihydroorotate dehydrogenase and nucleoside transport in MYCN-amplified neuroblastoma

Metabolic reprogramming is an integral part of the growth-promoting program driven by the MYC family of oncogenes. However, this reprogramming also imposes metabolic dependencies that could be exploited therapeutically. Here we report that the pyrimidine biosynthetic enzyme dihydroorotate dehydrogen...

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Detalles Bibliográficos
Autores principales: Yu, Yajie, Ding, Jane, Zhu, Shunqin, Alptekin, Ahmet, Dong, Zheng, Yan, Chunhong, Zha, Yunhong, Ding, Han-Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8405683/
https://www.ncbi.nlm.nih.gov/pubmed/34462431
http://dx.doi.org/10.1038/s41419-021-04120-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8405683/
https://www.ncbi.nlm.nih.gov/pubmed/34462431
http://dx.doi.org/10.1038/s41419-021-04120-w

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