Silencing of O-linked N-acetylglucosamine transferase ameliorates hypercalcemia-induced neurotoxicity in renal failure by regulating EZH2/KLF2/CXCL1 axis

Hypocalcemia, associated with Calcium neurotoxicity, has been reported to induce nerve dysfunction, which is a significant problem of renal failure. This study identifies a molecular mechanism of the O-linked N-acetylglucosamine transferase (OGT)-mediated enhancer of zeste homolog 2 (EZH2)/krüppel-l...

Descripción completa

Detalles Bibliográficos
Autores principales: Cao, Yaochen, Chen, Xin, Sun, Hongming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8405781/
https://www.ncbi.nlm.nih.gov/pubmed/34462420
http://dx.doi.org/10.1038/s41419-021-04022-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8405781/
https://www.ncbi.nlm.nih.gov/pubmed/34462420
http://dx.doi.org/10.1038/s41419-021-04022-x

Ejemplares similares