TFAM-deficient mouse skin fibroblasts – an ex vivo model of mitochondrial dysfunction

Mitochondrial dysfunction associates with several pathological processes and contributes to chronic inflammatory and ageing-related diseases. Mitochondrial transcription factor A (TFAM) plays a critical role in maintaining mtDNA integrity and function. Taking advantage of Tfam(fl/fl) UBC-Cre/ER(T2+/...

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Detalles Bibliográficos
Autores principales: Del Rey, Manuel J., Meroño, Carolina, Municio, Cristina, Usategui, Alicia, Mittelbrunn, María, García-Consuegra, Inés, Criado, Gabriel, Pablos, José L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8405849/
https://www.ncbi.nlm.nih.gov/pubmed/34312668
http://dx.doi.org/10.1242/dmm.048995

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8405849/
https://www.ncbi.nlm.nih.gov/pubmed/34312668
http://dx.doi.org/10.1242/dmm.048995

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