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Ymir: A 3D structural affinity model for multi-epitope vaccine simulations
Vaccine development is challenged by the hierarchy of immunodominance between target antigen epitopes and the emergence of antigenic variants by pathogen mutation. The strength and breadth of antibody responses relies on selection and mutation in the germinal center and on the structural similarity...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8405928/ https://www.ncbi.nlm.nih.gov/pubmed/34485861 http://dx.doi.org/10.1016/j.isci.2021.102979 |