The disordered regions of the methyltransferase SETD2 govern its function by regulating its proteolysis and phase separation

SETD2 is an important methyltransferase that methylates crucial substrates such as histone H3, tubulin, and STAT1 and also physically interacts with transcription and splicing regulators such as Pol II and various hnRNPs. Of note, SETD2 has a functionally uncharacterized extended N-terminal region,...

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Detalles Bibliográficos
Autores principales: Bhattacharya, Saikat, Lange, Jeffrey J., Levy, Michaella, Florens, Laurence, Washburn, Michael P., Workman, Jerry L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8405934/
https://www.ncbi.nlm.nih.gov/pubmed/34391778
http://dx.doi.org/10.1016/j.jbc.2021.101075

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8405934/
https://www.ncbi.nlm.nih.gov/pubmed/34391778
http://dx.doi.org/10.1016/j.jbc.2021.101075

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