Cargando…
The disordered regions of the methyltransferase SETD2 govern its function by regulating its proteolysis and phase separation
SETD2 is an important methyltransferase that methylates crucial substrates such as histone H3, tubulin, and STAT1 and also physically interacts with transcription and splicing regulators such as Pol II and various hnRNPs. Of note, SETD2 has a functionally uncharacterized extended N-terminal region,...
| Autores principales: | , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2021
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8405934/ https://www.ncbi.nlm.nih.gov/pubmed/34391778 http://dx.doi.org/10.1016/j.jbc.2021.101075 |