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CD147 mediates the CD44s-dependent differentiation of myofibroblasts driven by transforming growth factor-β(1)

Progressive fibrosis leads to loss of organ function and affects many organs as a result of excessive extracellular matrix production. The ubiquitous matrix polysaccharide hyaluronan (HA) is central to this through association with its primary receptor, CD44, which exists as standard CD44 (CD44s) or...

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Detalles Bibliográficos
Autores principales: Woods, Emma L., Grigorieva, Irina V., Midgley, Adam C., Brown, Charlotte V.M., Lu, Yueh-an, Phillips, Aled O., Bowen, Timothy, Meran, Soma, Steadman, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8405944/
https://www.ncbi.nlm.nih.gov/pubmed/34364871
http://dx.doi.org/10.1016/j.jbc.2021.100987