LAT1 inhibitor JPH203 sensitizes cancer cells to radiation by enhancing radiation-induced cellular senescence

L-type amino acid transporter 1 (LAT1) is important for transporting neutral amino acids into cells. LAT1 expression is correlated with cancer malignancy, suggesting that LAT1 is a promising target for cancer therapy. JPH203, a potential novel drug targeting LAT1, has been shown to suppress tumor gr...

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Detalles Bibliográficos
Autores principales: Bo, Tomoki, Kobayashi, Sho, Inanami, Osamu, Fujii, Junichi, Nakajima, Osamu, Ito, Tsunekata, Yasui, Hironobu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8405945/
https://www.ncbi.nlm.nih.gov/pubmed/34461558
http://dx.doi.org/10.1016/j.tranon.2021.101212

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8405945/
https://www.ncbi.nlm.nih.gov/pubmed/34461558
http://dx.doi.org/10.1016/j.tranon.2021.101212

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