D614G Substitution of SARS-CoV-2 Spike Protein Increases Syncytium Formation and Virus Titer via Enhanced Furin-Mediated Spike Cleavage

Since the D614G substitution in the spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged, the variant strain has undergone a rapid expansion to become the most abundant strain worldwide. Therefore, this substitution may provide an advantage for viral spreading. T...

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Detalles Bibliográficos
Autores principales: Cheng, Ya-Wen, Chao, Tai-Ling, Li, Chiao-Ling, Wang, Sheng-Han, Kao, Han-Chieh, Tsai, Ya-Min, Wang, Hurng-Yi, Hsieh, Chi-Ling, Lin, You-Yu, Chen, Pei-Jer, Chang, Sui-Yuan, Yeh, Shiou-Hwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8406174/
https://www.ncbi.nlm.nih.gov/pubmed/34311586
http://dx.doi.org/10.1128/mBio.00587-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8406174/
https://www.ncbi.nlm.nih.gov/pubmed/34311586
http://dx.doi.org/10.1128/mBio.00587-21

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