Engineered Type Six Secretion Systems Deliver Active Exogenous Effectors and Cre Recombinase

Genetic editing has revolutionized biotechnology, but delivery of endonuclease genes as DNA can lead to aberrant integration or overexpression, leading to off-target effects. Here, we develop a mechanism to deliver Cre recombinase as a protein by engineering the bacterial type six secretion system (...

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Detalles Bibliográficos
Autores principales: Hersch, Steven J., Lam, Linh, Dong, Tao G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8406194/
https://www.ncbi.nlm.nih.gov/pubmed/34281388
http://dx.doi.org/10.1128/mBio.01115-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8406194/
https://www.ncbi.nlm.nih.gov/pubmed/34281388
http://dx.doi.org/10.1128/mBio.01115-21

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