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Engineered Type Six Secretion Systems Deliver Active Exogenous Effectors and Cre Recombinase
Genetic editing has revolutionized biotechnology, but delivery of endonuclease genes as DNA can lead to aberrant integration or overexpression, leading to off-target effects. Here, we develop a mechanism to deliver Cre recombinase as a protein by engineering the bacterial type six secretion system (...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Microbiology
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8406194/ https://www.ncbi.nlm.nih.gov/pubmed/34281388 http://dx.doi.org/10.1128/mBio.01115-21 |