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SAMase of Bacteriophage T3 Inactivates Escherichia coli’s Methionine S-Adenosyltransferase by Forming Heteropolymers
S-Adenosylmethionine lyase (SAMase) of bacteriophage T3 degrades the intracellular SAM pools of the host Escherichia coli cells, thereby inactivating a crucial metabolite involved in a plethora of cellular functions, including DNA methylation. SAMase is the first viral protein expressed upon infecti...
Autores principales: | Simon-Baram, Hadas, Kleiner, Daniel, Shmulevich, Fannia, Zarivach, Raz, Zalk, Ran, Tang, Huayuan, Ding, Feng, Bershtein, Shimon |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Microbiology
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8406200/ https://www.ncbi.nlm.nih.gov/pubmed/34340545 http://dx.doi.org/10.1128/mBio.01242-21 |
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