Clinically Relevant Mutations of Mycobacterial GatCAB Inform Regulation of Translational Fidelity

Most bacteria employ a two-step indirect tRNA aminoacylation pathway for the synthesis of aminoacylated tRNA(Gln) and tRNA(Asn). The heterotrimeric enzyme GatCAB performs a critical amidotransferase reaction in the second step of this pathway. We have previously demonstrated in mycobacteria that thi...

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Detalles Bibliográficos
Autores principales: Li, Yang-Yang, Cai, Rong-Jun, Yang, Jia-Ying, Hendrickson, Tamara L., Xiang, Ye, Javid, Babak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8406222/
https://www.ncbi.nlm.nih.gov/pubmed/34225495
http://dx.doi.org/10.1128/mBio.01100-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8406222/
https://www.ncbi.nlm.nih.gov/pubmed/34225495
http://dx.doi.org/10.1128/mBio.01100-21

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