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Clinically Relevant Mutations of Mycobacterial GatCAB Inform Regulation of Translational Fidelity
Most bacteria employ a two-step indirect tRNA aminoacylation pathway for the synthesis of aminoacylated tRNA(Gln) and tRNA(Asn). The heterotrimeric enzyme GatCAB performs a critical amidotransferase reaction in the second step of this pathway. We have previously demonstrated in mycobacteria that thi...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Microbiology
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8406222/ https://www.ncbi.nlm.nih.gov/pubmed/34225495 http://dx.doi.org/10.1128/mBio.01100-21 |