Epstein-Barr Virus Induced Cytidine Metabolism Roles in Transformed B-Cell Growth and Survival

Epstein-Barr virus (EBV) is associated with 200,000 cancers annually, including B-cell lymphomas in immunosuppressed hosts. Hypomorphic mutations of the de novo pyrimidine synthesis pathway enzyme cytidine 5′ triphosphate synthase 1 (CTPS1) suppress cell-mediated immunity, resulting in fulminant EBV...

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Detalles Bibliográficos
Autores principales: Liang, Jin Hua, Wang, Chong, Yiu, Stephanie Pei Tung, Zhao, Bo, Guo, Rui, Gewurz, Benjamin E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8406234/
https://www.ncbi.nlm.nih.gov/pubmed/34281398
http://dx.doi.org/10.1128/mBio.01530-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8406234/
https://www.ncbi.nlm.nih.gov/pubmed/34281398
http://dx.doi.org/10.1128/mBio.01530-21

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