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Epstein-Barr Virus Induced Cytidine Metabolism Roles in Transformed B-Cell Growth and Survival
Epstein-Barr virus (EBV) is associated with 200,000 cancers annually, including B-cell lymphomas in immunosuppressed hosts. Hypomorphic mutations of the de novo pyrimidine synthesis pathway enzyme cytidine 5′ triphosphate synthase 1 (CTPS1) suppress cell-mediated immunity, resulting in fulminant EBV...
Autores principales: | Liang, Jin Hua, Wang, Chong, Yiu, Stephanie Pei Tung, Zhao, Bo, Guo, Rui, Gewurz, Benjamin E. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Microbiology
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8406234/ https://www.ncbi.nlm.nih.gov/pubmed/34281398 http://dx.doi.org/10.1128/mBio.01530-21 |
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