In Vivo Therapy with M2e-Specific IgG Selects for an Influenza A Virus Mutant with Delayed Matrix Protein 2 Expression

The ectodomain of matrix protein 2 (M2e) of influenza A viruses is a universal influenza A vaccine candidate. Here, we report potential evasion strategies of influenza A viruses under in vivo passive anti-M2e IgG immune selection pressure in severe combined immune-deficient (SCID) mice. A/Puerto Ric...

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Detalles Bibliográficos
Autores principales: Van den Hoecke, Silvie, Ballegeer, Marlies, Vrancken, Bram, Deng, Lei, Job, Emma R., Roose, Kenny, Schepens, Bert, Van Hoecke, Lien, Lemey, Philippe, Saelens, Xavier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8406285/
https://www.ncbi.nlm.nih.gov/pubmed/34253060
http://dx.doi.org/10.1128/mBio.00745-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8406285/
https://www.ncbi.nlm.nih.gov/pubmed/34253060
http://dx.doi.org/10.1128/mBio.00745-21

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