Cargando…
In Vivo Therapy with M2e-Specific IgG Selects for an Influenza A Virus Mutant with Delayed Matrix Protein 2 Expression
The ectodomain of matrix protein 2 (M2e) of influenza A viruses is a universal influenza A vaccine candidate. Here, we report potential evasion strategies of influenza A viruses under in vivo passive anti-M2e IgG immune selection pressure in severe combined immune-deficient (SCID) mice. A/Puerto Ric...
Autores principales: | Van den Hoecke, Silvie, Ballegeer, Marlies, Vrancken, Bram, Deng, Lei, Job, Emma R., Roose, Kenny, Schepens, Bert, Van Hoecke, Lien, Lemey, Philippe, Saelens, Xavier |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Microbiology
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8406285/ https://www.ncbi.nlm.nih.gov/pubmed/34253060 http://dx.doi.org/10.1128/mBio.00745-21 |
Ejemplares similares
-
A GFP Expressing Influenza A Virus to Report In Vivo Tropism and Protection by a Matrix Protein 2 Ectodomain-Specific Monoclonal Antibody
por: De Baets, Sarah, et al.
Publicado: (2015) -
The Opposing Effect of Type I IFN on the T Cell Response by Non-modified mRNA-Lipoplex Vaccines Is Determined by the Route of Administration
por: Van Hoecke, Lien, et al.
Publicado: (2020) -
Selective Engagement of FcγRIV by a M2e-Specific Single Domain Antibody Construct Protects Against Influenza A Virus Infection
por: De Vlieger, Dorien, et al.
Publicado: (2019) -
How mRNA therapeutics are entering the monoclonal antibody field
por: Van Hoecke, Lien, et al.
Publicado: (2019) -
mRNA Encoding a Bispecific Single Domain Antibody Construct Protects against Influenza A Virus Infection in Mice
por: Van Hoecke, Lien, et al.
Publicado: (2020)