SARS-CoV-2 Bearing a Mutation at the S1/S2 Cleavage Site Exhibits Attenuated Virulence and Confers Protective Immunity

Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) possesses a discriminative polybasic cleavage motif in its spike protein that is recognized by the host furin protease. Proteolytic cleavage activates the spike protein, thereby affecting both the cellular entry pathway and cell tropism of...

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Detalles Bibliográficos
Autores principales: Sasaki, Michihito, Toba, Shinsuke, Itakura, Yukari, Chambaro, Herman M., Kishimoto, Mai, Tabata, Koshiro, Intaruck, Kittiya, Uemura, Kentaro, Sanaki, Takao, Sato, Akihiko, Hall, William W., Orba, Yasuko, Sawa, Hirofumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8406294/
https://www.ncbi.nlm.nih.gov/pubmed/34425707
http://dx.doi.org/10.1128/mBio.01415-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8406294/
https://www.ncbi.nlm.nih.gov/pubmed/34425707
http://dx.doi.org/10.1128/mBio.01415-21

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